High-Dose Folic Acid Does Not Prevent High Blood Pressure of Pregnancy

Some studies suggest which taking high doses of folic acid can prevent pre-eclampsia, although a randomized trial found the idea did not.

Nicholas Bakalar

Some experts believe which a high daily dose of folic acid can reduce the risk for pre-eclampsia, the dangerous high blood pressure which can occur during pregnancy. A randomized trial has found which the idea does not work.

Folic acid in modest doses can be proven to reduce the risk for the serious birth defects of the brain or spinal cord called neural tube defects, so prenatal vitamins contain the nutrient. although some epidemiological evidence has suggested which the more folic acid taken, the lower the risk for pre-eclampsia.

Researchers tested which hypothesis that has a group of 2,464 women who had at least one risk factor for pre-eclampsia, such as high blood pressure or diabetes. Half received 4.0 milligrams of folic acid a day, as well as half got daily placebo tablets along with 1.1 milligrams of folic acid. The study can be in BMJ.

There was no difference between the groups in incidence of pre-eclampsia or any different negative outcome, such as stillbirth, they tracked.

Why not take the larger dose, just in case? The senior author, Dr. Mark C. Walker, chairman of obstetrics as well as gynecology at the University of Ottawa, said we do not know what the long-term effects are. “There are so many times in medicine where things go coming from panacea to prescription to poison. I’m advising people to take a regular multivitamin, as well as which’s the idea.”