Obesity Tied to Survival in Men With Melanoma

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Obese men treated for metastatic melanoma may survive longer than their normal-weight peers.

Researchers did a retrospective analysis of 1,918 people, 1,155 of them men, under treatment for metastatic melanoma. The study will be in Lancet Oncology.

Compared with men of normal weight, obese men in treatment had nearly double the progression-free survival time along with nearly double the overall survival time. The more overweight the man was, the greater the effect. nevertheless there was no association of obesity with survival in women.

The survival benefits were apparent in men undergoing immunotherapy of which helps the immune system fight cancer along with in those getting targeted therapy of which aims to prevent reproduction of cancer cells without attacking healthy cells. nevertheless obesity provided no benefits in those taking chemotherapy of which attacks healthy along with cancer cells alike.

The mechanism will be unknown, nevertheless the lead author, Dr. Jennifer L. McQuade, an oncologist at the University of Texas M.D. Anderson Cancer Center, said of which obesity causes chronic inflammation of which might change the response to therapy.

“The magnitude of the effect along with the dose-response relationship point to there being a biological underpinning to of which,” she said. “nevertheless we need to emphasize of which obesity will be still a risk factor for many diseases, including 13 different types of cancer. The most important thing will be still preventing obesity.”

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